TUESDAY 1st December

8:30 - 10:00

Registration

09:45

Welcome

Chair: E. Melo

10:00 - 11:00

Invited Speaker: HOLGER WILLE

"The infectious prion: A four-rung beta-solenoid structure, however you look at it"

11:00 - 11:30

Coffee Break and Poster Discussion

Chairs: J. Requena and E. Melo

11:30 - 13:00

Oral Communications:

J. CASTILLA
"Infectious recombinant prions: In vitro generation and propagation of different strains"

AM. SEVILLANO
"The architecture of recombinants prions is similar to that of brain-derived prions: insight from limited proteolysis"

SR. ELEZGARAI
"Employing dynamic mass redistribution to identify pharmacological chaperones for the cellular prion protein"

13:00 - 14:30

Lunch

Chairs: J. Castilla and J. Requena

14:30 - 16:00

Short Oral Communications:

E. BIASINI
"A cationic tetrapyrrole is a functional inhibitor of the cellular prion protein"

E. MELO
"Getting proteins more compact prevents protein amyloidosis"

S. VENTURA
"Identification of prion-like proteins in proteomes"

JA. MACEDO
"Membrane-enriched proteomic changes associated with prion protein expression during neural differentiation and in neuroblastoma cells"

16:00 - 16:30

Coffee Break and Poster Discussion

Chairs: T. Mayoral and C. Machado

16:30 - 18:30

Oral Communications:

R. BUJDOSO
"Faithful replication of mammalian prions in Drosophila"

O. ANDRÉOLETTI
"Mono-nucleated blood cell populations display different abilities to transmit prion disease by the transfusion route"

S. GILCH
"A polymorphism in the hydrophobic core region of deer PrP modulates biochemical and biological properties of chronic wasting disease prions"

Short Oral Communications:

A. OTERO
"Effects of N158D canine substitution on prion infected mice"

N. FERNÁNDEZ-BORGES
"A comprehensive study of the potential resistance of the canidae family to prion infection"

PL. ACUTIS
"Prospects for applying breeding for scrapie resistance in goats: the current situation in italy"

20:30

Congress Dinner

    WEDNESDAY 2nd December

- PRION DISEASES IN ANIMALS - 

Chair: L. Orge

9:00 - 10:00

Invited Speaker: TIMM KONOLD

"Clinical disease in transmissible spongiform encephalopathies of ruminants"

10:00 - 11:00

Chairs: J. Badiola and L. Orge

Oral Communications:

JM. TOIVONEN
"Analysis of candidate microRNA biomarkers in classical scrapie sheep"

Short Oral Communications:

R. NONNO
"A single amino acid polymorphism in the bank vole prion protein determines strain fidelity upon experimental transmission of L-type bovine spongiform encephalopathy"

JC. ESPINOSA
"Comparison of the transmission features of several prion strains in a transgenic mouse model and in its natural counterpart"

11:00 - 11:30

Coffee Break and Poster Discussion

I. GONZALO
"Diversity of PrPd immunorreactivity pattern in atypical Spanish scrapie cases"

C. MACHADO
"Portuguese retrospective BSE typing"

Chair: C. Oliveira

12: 00 - 13:00

Invited Speaker: TIAGO OUTEIRO

"From the baker to the bedside: unraveling the molecular mechanisms of Parkinson´s disease"

13:00 - 14:30

Lunch

Chairs: J. Castilla and I. Baldeiras

Oral Communications:

L. PIRISINU
"The brains of patients with Gerstmann-Sträussler-Scheinker disease (GSS) harbor transmissible prions"

F. LLORENS
"Pathological and molecular features in Fatal Familial Insomnia: new insights"

W. TAHIR
"Cross talk on the role of PARK7 (DJ-1) in pathophysiology of sporadic Creutzfeldt-Jakob diseases (CJD) in cerebellum in MM1 and VV2 subtypes"

16:00 - 16:30

Coffee Break and Poster Discussion

Chairs: J. M. Torres and R. Carvalho

Short Oral Communications:

B. ANSOLEAGA
"Deregulation of mitochondrial metabolism, protein synthesis and purine metabolism in Creutzfeldt-Jakob disease"

MC. GUERRERO
"Taupatía con rasgos de degeneración corticobasal en la enfermedad de Creutzfeldt-Jakob: perfil neuropatológico y clínico en una serie de casos de banco de cerebros"

M. GARCÉS
"Morphological approach to glial involvement in prion and a prion-like diseases"

MJ. LEITÃO
"Novel assay for detection of CSF 14-3-3γ levels increases sCJD diagnosis accuracy"